Sugi Predict

Sugi Predict / Compounds / SCHEMBL2461277

SCHEMBL2461277

SCHEMBL2461277

Cl[N+]12C=CN=CC1=C(c1ccc3ccccc3c1)N=C2c1cccc(OCc2ccccc2)c1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 1/20 0.40
▸ F9 P00740 1/20 0.39
▸ F10 P00742 1/20 0.39
▸ DHODH Q02127 4/20 0.36
▸ NR1H2 P55055 1/20 0.36
▸ MRGPRX4 Q96LA9 2/20 0.36
▸ PDE10A Q9Y233 1/20 0.36
▸ BACE1 P56817 1/20 0.36
▸ ANO1 Q5XXA6 2/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ CYP4F2 P78329 1/20 0.35
▸ CYP4A11 Q02928 1/20 0.35
▸ HDAC4 P56524 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2456978 0.92 MRGPRX4 (0.40) F9F10NR1H2MRGPRX4BACE1
SCHEMBL2459986 0.90 TSHR (0.39) NR1H2MRGPRX4BACE1CYP4F2CYP4A11
SCHEMBL2462894 0.88 ALOX5 (0.41) ALOX5F9F10DHODHNR1H2
SCHEMBL2463359 0.87 NR1H2 (0.39) ALOX5F9F10DHODHNR1H2
SCHEMBL2458350 0.85 MRGPRX4 (0.38) DHODHNR1H2MRGPRX4BACE1CYP4F2
SCHEMBL2465962 0.84 NR1H2 (0.42) ALOX5NR1H2MRGPRX4HDAC4
SCHEMBL2462309 0.84 MRGPRX4 (0.43) NR1H2MRGPRX4
SCHEMBL2460371 0.82 NR1H2 (0.42) NR1H2MRGPRX4BACE1CYP4F2CYP4A11
SCHEMBL2460381 0.82 MAOB (0.38) NR1H2MRGPRX4CYP4F2CYP4A11
SCHEMBL2460621 0.82 NR1H2 (0.39) DHODHNR1H2MRGPRX4CYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 ALOX5 4577/4885F9 4236/4885F10 3668/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 ALOX5 4577/4885F9 4236/4885F10 3668/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 ALOX5 4577/4885F9 4236/4885F10 3668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.