Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CTSV | O60911 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31426422 | 0.83 | PIN1 (0.50) | PIN1POLBMEN1KMT2AMAPT | |
| SCHEMBL16060171 | 0.80 | PIN1 (0.50) | PIN1POLBMEN1KMT2AMAPT | |
| SCHEMBL31234027 | 0.78 | PIN1 (0.53) | PIN1POLBMEN1KMT2AMAPT | |
| SCHEMBL1937604 | 0.78 | PIN1 (0.53) | PIN1POLBMEN1KMT2AMAPT | |
| SCHEMBL8546360 | 0.77 | PIN1 (0.50) | PIN1POLBMEN1KMT2AMAPT | |
| SCHEMBL3922556 | 0.76 | RXRA (0.52) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL573839 | 0.75 | CTSV (0.49) | PIN1POLBMEN1KMT2AMAPT | |
| SCHEMBL29447092 | 0.74 | MAPT (0.59) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL4879420 | 0.74 | POLB (0.57) | PIN1POLBMEN1KMT2AMAPT | |
| SCHEMBL564270 | 0.74 | MAPT (0.59) | POLBMEN1KMT2AMAPTCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4083038-A1 | PYRIDAZINYL THIAZOLECARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |
| US-20220315603-A1 | PYRIDAZINYL-THIAZOLECARBOXAMIDE COMPOUND | KOTOBUKI PHARMACEUTICAL CO., LTD. (JP) | 2022-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220315603-A1 | PYRIDAZINYL-THIAZOLECARBOXAMIDE COMPOUND | CD274, PDCD1, PDCD1LG2 | PIN1 1664/4885POLB 1637/4885MEN1 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.