SCHEMBL2463541

SCHEMBL2463541

NC(=O)[C@@]1(n2cnc3c(N)ncnc32)O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 5/20 0.50
ADORA2A P29274 4/20 0.50
SLC28A1 O00337 2/20 0.50
PI4KA P42356 2/20 0.50
PI4K2B Q8TCG2 2/20 0.50
PI4K2A Q9BTU6 2/20 0.50
PI4KB Q9UBF8 2/20 0.50
ADORA1 P30542 2/20 0.50
ADORA2B P29275 2/20 0.50
DPP4 P27487 1/20 0.50
MEN1 O00255 1/20 0.50
MAP3K7 O43318 1/20 0.50
SLC28A2 O43868 1/20 0.50
GAPDH P04406 1/20 0.50
MAPK1 P28482 1/20 0.50
STAT6 P42226 1/20 0.50
KMT2A Q03164 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
DOT1L Q8TEK3 1/20 0.50
SLC29A1 Q99808 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL27715158 0.93 ADORA3 (0.45) ADORA3ADORA2ASLC28A1PI4KAPI4K2B
SCHEMBL29655156 0.91 ADORA3 (0.50) ADORA3ADORA2ASLC28A1PI4KAPI4K2B
SCHEMBL219553 0.90 ADORA3 (0.49) ADORA3ADORA2ASLC28A1PI4KAPI4K2B
SCHEMBL27653575 0.89 ADORA3 (0.48) ADORA3ADORA2ASLC28A1PI4KAPI4K2B
SCHEMBL30042226 0.89 PI4KA (0.39) ADORA3ADORA2ASLC28A1PI4KAPI4K2B
SCHEMBL2761283 0.87 PI4KA (0.47) ADORA3ADORA2ASLC28A1PI4KAPI4K2B
Phosphoric Acid SCHEMBL474409 0.86 ADORA1 (0.48) ADORA3ADORA2ASLC28A1PI4KAPI4K2B
SCHEMBL2480947 0.86 PI4KA (0.46) ADORA3ADORA2ASLC28A1PI4KAPI4K2B
SCHEMBL2480939 0.86 PI4KA (0.46) ADORA3ADORA2ASLC28A1PI4KAPI4K2B
SCHEMBL30211760 0.86 PI4KA (0.46) ADORA3ADORA2ASLC28A1PI4KAPI4K2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 857 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117413065-A Constructs, methods and uses for the preparation of circular RNAs 上海环码生物医药有限公司 2024-01-16 CN claimed
CN-117222741-A Site-specific genomic modification techniques 北卡罗来纳大学 2023-12-12 CN claimed
CN-116916936-A Compositions and methods for delivering RNA 再生技术有限责任公司 2023-10-20 CN claimed
CN-114929244-A Mannose-based mRNA targeted delivery system and application thereof 深圳市瑞吉生物科技有限公司 2022-08-19 CN claimed
US-20210108252-A1 LABEL-FREE ANALYSIS OF RNA CAPPING EFFICIENCY USING RNASE H, PROBES AND LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY NOVARTIS AG (CH) 2021-04-15 US claimed
CN-111744019-A Mannose-based mRNA (messenger ribonucleic acid) targeted delivery system and application thereof 深圳市瑞吉生物科技有限公司 2020-10-09 CN claimed
EP-3656872-A1 LABEL-FREE ANALYSIS OF RNA CAPPING EFFICIENCY USING RNASE H, PROBES AND LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY Novartis AG (CH) 2020-05-27 EP claimed
EP-3387150-B1 LABEL-FREE ANALYSIS OF RNA CAPPING EFFICIENCY USING RNASE H, PROBES AND LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY NOVARTIS AG (CH) 2019-10-02 EP claimed
EP-3387150-A1 LABEL-FREE ANALYSIS OF RNA CAPPING EFFICIENCY USING RNASE H, PROBES AND LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY Novartis AG (CH) 2018-10-17 EP claimed
US-9719084-B2 Co-transcriptional assembly of modified RNA nanoparticles THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 2017-08-01 US claimed
WO-2017098468-A1 LABEL-FREE ANALYSIS OF RNA CAPPING EFFICIENCY USING RNASE H, PROBES AND LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY NOVARTIS AG (CH) 2017-06-15 WO claimed
CN-104870022-A In vivo production of proteins modeRNA Therapeutics 2015-08-26 CN claimed
US-20150203842-A1 CO-TRANSCRIPTIONAL ASSEMBLY OF MODIFIED RNA NANOPARTICLES THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES 2015-07-23 US claimed
CN-103764169-A Perfluorinated compounds for non-viral transfer of nucleic acids SCHAEFER KONSTANZE 2014-04-30 CN claimed
CN-103687957-A Engineered nucleic acids and methods for their use in non-human vertebrates modeRNA Therapeutics 2014-03-26 CN claimed
WO-2014039809-A2 CO-TRANSCRIPTIONAL ASSEMBLY OF MODIFIED RNA NANOPARTICLES THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 2014-03-13 WO claimed
EP-2578685-A2 RNA containing modified nucleosides and methods of use thereof The Trustees of The University of Pennsylvania (US) 2013-04-10 EP claimed
EP-2547379-A1 MOLECULARLY IMPRINTED POLYMERS FOR ELIMINATING METABOLITES Fresenius Medical Care Deutschland GmbH (DE) 2013-01-23 EP claimed
WO-2011113607-A1 MOLECULARLY IMPRINTED POLYMERS FOR ELIMINATING METABOLITES FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (DE) 2011-09-22 WO claimed
CN-101855351-A Compositions and methods for the identification of inhibitors of retroviral infection TRANA DISCOVERY 2010-10-06 CN claimed