Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.62 |
| ▸ | NPC1 | O15118 | 9/20 | 0.62 |
| ▸ | PKM | P14618 | 9/20 | 0.62 |
| ▸ | TP53 | P04637 | 8/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | GRM5 | P41594 | 4/20 | 0.58 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462019 | 0.84 | NPC1 (0.49) | RAB9ANPC1PKMTP53SMN1; SMN2 | |
| SCHEMBL11800551 | 0.82 | HPGD (0.49) | RAB9ANPC1MAPTGRM5PLCG2 | |
| SCHEMBL2458069 | 0.81 | NPC1 (0.58) | RAB9ANPC1PKMTP53SMN1; SMN2 | |
| SCHEMBL2459257 | 0.78 | MAPT (0.65) | RAB9ANPC1PKMTP53SMN1; SMN2 | |
| SCHEMBL2462953 | 0.77 | RAB9A (0.60) | RAB9ANPC1PKMSMN1; SMN2MAPT | |
| SCHEMBL5959914 | 0.76 | NPC1 (0.63) | RAB9ANPC1PKMTP53SMN1; SMN2 | |
| SCHEMBL5959921 | 0.76 | RAB9A (0.75) | RAB9ANPC1PKMTP53SMN1; SMN2 | |
| SCHEMBL2463030 | 0.76 | CHRNB2 (0.64) | RAB9ANPC1PKMTP53SMN1; SMN2 | |
| SCHEMBL2456535 | 0.75 | NPC1 (0.47) | RAB9ANPC1TP53SMN1; SMN2MAPT | |
| SCHEMBL2461726 | 0.74 | RAB9A (0.52) | RAB9ANPC1PKMTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110294856-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | DAHL BJARNE H (DK) | 2011-12-01 | — | — | US | disclosed |
| US-8017631-B2 | Oxadiazole derivatives and their medical use | NEUROSEARCH A/S (DK) | 2011-09-13 | — | — | US | disclosed |
| EP-2255848-A2 | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer | NeuroSearch AS (DK) | 2010-12-01 | — | — | EP | disclosed |
| US-20100234349-A1 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | NEUROSEARCH A/S (DK) | 2010-09-16 | — | — | US | disclosed |
| US-20090312347-A1 | Novel oxadiazole derivatives and their medical use | SANIONA A/S (DK) | 2009-12-17 | — | — | US | disclosed |
| EP-1881979-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006114400-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312347-A1 | Novel oxadiazole derivatives and their medical use | CHRNA3, CHRNA5, CHRNB3 | RAB9A 4260/4885NPC1 4073/4885PKM 1333/4885 |
| US-20100234349-A1 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER | CHRNA10, CHRNA4, CHRNA5 | RAB9A 2472/4885NPC1 3329/4885PKM 2357/4885 |
| US-20110294856-A1 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE | CHRNA3, CHRNA5, CHRNB3 | RAB9A 4260/4885NPC1 4073/4885PKM 1333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.