Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20564577 | 0.83 | SMN1; SMN2 (0.46) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL16702802 | 0.83 | KMT2A (0.53) | MEN1KMT2AKDM4ECXCL8SMN1; SMN2 | |
| SCHEMBL19950428 | 0.80 | TSHR (0.42) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL29182440 | 0.79 | VSIR (0.39) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL286505 | 0.78 | FFAR1 (0.45) | MEN1KMT2ASMN1; SMN2ALDH1A1MPO | |
| SCHEMBL31033368 | 0.78 | FFAR1 (0.45) | MEN1KMT2ASMN1; SMN2ALDH1A1MPO | |
| SCHEMBL24643278 | 0.78 | MEN1 (0.37) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL30558299 | 0.78 | CXCL8 (0.53) | MEN1KMT2AKDM4ECXCL8ALDH1A1 | |
| SCHEMBL25679309 | 0.78 | CXCL8 (0.53) | MEN1KMT2AKDM4ECXCL8ALDH1A1 | |
| SCHEMBL22513302 | 0.77 | PDCD1LG2 (0.45) | MEN1KMT2ASMN1; SMN2ALDH1A1MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117500811-A | Covalent RAS inhibitors and uses thereof | 锐新医药公司 | 2024-02-02 | — | — | CN | disclosed |
| WO-2022235866-A1 | COVALENT RAS INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2022-11-10 | — | — | WO | disclosed |