Sugi Predict

Sugi Predict / Compounds / SCHEMBL2464455

SCHEMBL2464455

SCHEMBL2464455

COC=C1CC(C2=C3C=NC=C[N+]3(Cl)C(c3cccc(OCc4ccccc4)c3)=N2)C1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ERN1 O75460 1/20 0.35
▸ PDE10A Q9Y233 1/20 0.34
▸ MAOB P27338 1/20 0.34
▸ IGF1R P08069 8/20 0.33
▸ TNK2 Q07912 1/20 0.33
▸ BRD4 O60885 1/20 0.33
▸ CREBBP Q92793 1/20 0.33
▸ NR1H2 P55055 1/20 0.33
▸ CHRNB2 P17787 3/20 0.32
▸ CHRNB4 P30926 3/20 0.32
▸ CHRNA3 P32297 3/20 0.32
▸ CHRNA7 P36544 3/20 0.32
▸ CHRNA4 P43681 3/20 0.32
▸ MRGPRX4 Q96LA9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2459767 0.89 IGF1R (0.36) ERN1PDE10AMAOBIGF1RTNK2
SCHEMBL2459426 0.87 BRD4 (0.36) PDE10AMAOBBRD4CREBBPNR1H2
SCHEMBL2460207 0.87 NR1H2 (0.35) PDE10AIGF1RTNK2BRD4CREBBP
SCHEMBL2460301 0.85 IGF1R (0.35) ERN1PDE10AMAOBIGF1RNR1H2
SCHEMBL2463346 0.85 IGF1R (0.35) PDE10AIGF1RTNK2NR1H2MRGPRX4
SCHEMBL2465897 0.84 F9 (0.34) ERN1PDE10AMAOBIGF1RTNK2
SCHEMBL2463487 0.83 PRMT5 (0.38) IGF1RCHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL2460369 0.83 IGF1R (0.38) PDE10AIGF1RTNK2NR1H2MRGPRX4
SCHEMBL2459920 0.83 IGF1R (0.38) ERN1MAOBIGF1RMRGPRX4
SCHEMBL2459447 0.83 PDE10A (0.33) ERN1PDE10AMAOBIGF1RTNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US disclosed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US disclosed
EP-1675860-A2 IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS OSI Pharmaceuticals, Inc. (US) 2006-07-05 — — EP disclosed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US disclosed
WO-2005037836-A2 IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 ERN1 2591/4885PDE10A 2449/4885MAOB 1546/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 ERN1 2591/4885PDE10A 2449/4885MAOB 1546/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 ERN1 2591/4885PDE10A 2449/4885MAOB 1546/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.