Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467186 | 0.84 | ALDH1A1 (0.33) | SCN9AALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL14634068 | 0.73 | EPHB4 (0.47) | CYP3A4LRRK2 | |
| SCHEMBL14634091 | 0.71 | EPHB4 (0.46) | LRRK2 | |
| SCHEMBL2439775 | 0.67 | KDR (0.48) | CYP3A4 | |
| SCHEMBL2469062 | 0.67 | RIPK2 (0.39) | SCN9ALRRK2 | |
| SCHEMBL14633989 | 0.66 | SYK (0.42) | CYP3A4LRRK2 | |
| SCHEMBL2541545 | 0.66 | MTOR (0.30) | — | |
| SCHEMBL2469140 | 0.65 | — | — | |
| SCHEMBL2435813 | 0.65 | EGFR (0.45) | — | |
| SCHEMBL2466508 | 0.63 | CDK9 (0.40) | PLK4CYP1A2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552211-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011120025-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |