Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464784 | 0.84 | SLC40A1 (0.33) | ALDH1A1CYP1A2CYP3A4SCN9AALOX15 | |
| SCHEMBL14634235 | 0.73 | EPHB4 (0.43) | CYP1A2CYP3A4CYP2D6PI4KB | |
| SCHEMBL2466363 | 0.67 | CHEK1 (0.36) | — | |
| SCHEMBL14634005 | 0.67 | LRRK2 (0.42) | — | |
| SCHEMBL14633696 | 0.66 | KDR (0.45) | CYP1A2CYP3A4CYP2D6KMT2API4KB | |
| SCHEMBL2469140 | 0.66 | — | — | |
| SCHEMBL2464853 | 0.65 | EED (0.30) | — | |
| SCHEMBL2463536 | 0.65 | ADORA3 (0.40) | — | |
| SCHEMBL14634068 | 0.62 | EPHB4 (0.47) | CYP3A4CYP2D6 | |
| SCHEMBL14633956 | 0.62 | ABCB11 (0.53) | CYP1A2CYP3A4CYP2D6PI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011120025-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |