Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 10/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NQO1 | P15559 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29490008 | 1.00 | KEAP1 (0.38) | KEAP1NFE2L2SMN1; SMN2NPC1LMNA | |
| SCHEMBL29442705 | 0.87 | NFE2L2 (0.46) | KEAP1NFE2L2 | |
| SCHEMBL16831673 | 0.87 | NFE2L2 (0.46) | KEAP1NFE2L2 | |
| SCHEMBL24650660 | 0.86 | NFE2L2 (0.40) | KEAP1NFE2L2SMN1; SMN2NPC1LMNA | |
| SCHEMBL24650638 | 0.85 | KEAP1 (0.40) | KEAP1NFE2L2SMN1; SMN2NPC1LMNA | |
| SCHEMBL29489994 | 0.85 | KEAP1 (0.40) | KEAP1NFE2L2SMN1; SMN2NPC1LMNA | |
| SCHEMBL31470223 | 0.84 | KEAP1 (0.46) | KEAP1NFE2L2NQO1 | |
| SCHEMBL24650071 | 0.84 | KEAP1 (0.40) | KEAP1NFE2L2NQO1 | |
| SCHEMBL29442620 | 0.84 | KEAP1 (0.40) | KEAP1NFE2L2NQO1 | |
| SCHEMBL20313343 | 0.82 | KDM4E (0.42) | KEAP1NFE2L2SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259223-A1 | BENZOTRIAZOLE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2022-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259223-A1 | BENZOTRIAZOLE DERIVATIVE | KEAP1, NFE2L2, BACH1 | KEAP1 1/4885NFE2L2 2/4885SMN1; SMN2 3374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.