Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PYGB | P11216 | 1/20 | 0.36 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.35 |
| ▸ | CD69 | Q07108 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20657365 | 0.78 | KDM4E (0.48) | CA2CA9MAPK1PYGBLGALS8 | |
| SCHEMBL28461019 | 0.78 | KDM4E (0.48) | CA2CA9MAPK1PYGBLGALS8 | |
| SCHEMBL6674579 | 0.78 | KDM4E (0.48) | CA2CA9MAPK1PYGBLGALS8 | |
| SCHEMBL25007179 | 0.77 | ALDH1A1 (0.65) | ALDH1A1THRBMAPK1LGALS8CD69 | |
| SCHEMBL23264564 | 0.76 | MAPK1 (0.51) | ALDH1A1THRBCA2CA9MAPK1 | |
| SCHEMBL16561892 | 0.74 | L3MBTL1 (0.51) | L3MBTL1LGALS8GAATYRMAPT | |
| SCHEMBL16561970 | 0.74 | L3MBTL1 (0.51) | L3MBTL1LGALS8GAATYRMAPT | |
| SCHEMBL7794001 | 0.72 | L3MBTL1 (0.42) | L3MBTL1LGALS8GAATYRMAPT | |
| SCHEMBL7790626 | 0.70 | LGALS8 (0.42) | L3MBTL1LGALS8GAATYRMAPT | |
| SCHEMBL2221093 | 0.69 | CA1 (0.54) | CA2CA9PYGBCA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022246266-A1 | BASE EDITING OF TRANSTHYRETIN GENE | BEAM THERAPEUTICS INC. (US) | 2022-11-24 | — | — | WO | disclosed |