SCHEMBL24665373 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	LTA4H	P09960	2/20	0.38

▸	MAPT	P10636	2/20	0.37

▸	SCN9A	Q15858	3/20	0.36

▸	FFAR1	O14842	2/20	0.36

▸	THRB	P10828	1/20	0.36

▸	PKM	P14618	1/20	0.35

▸	HTT	P42858	1/20	0.35

▸	GRN	P28799	2/20	0.34

▸	SORT1	Q99523	2/20	0.34

▸	IDH1	O75874	2/20	0.34

▸	HDAC1	Q13547	1/20	0.34

▸	HDAC6	Q9UBN7	1/20	0.34

▸	HDAC5	Q9UQL6	1/20	0.34

▸	KCNH2	Q12809	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL30005383	1.00	LTA4H (0.38)	LTA4HMAPTSCN9AFFAR1THRB
SCHEMBL30006457	0.92	LTA4H (0.45)	LTA4HSCN9AHDAC6KCNH2
SCHEMBL29123526	0.90	PTPN1 (0.42)	MAPTSCN9AFFAR1THRBGRN
SCHEMBL27243633	0.89	LTA4H (0.40)	LTA4HMAPTSCN9AFFAR1THRB
SCHEMBL27243634	0.89	LTA4H (0.40)	LTA4HMAPTSCN9AFFAR1THRB
SCHEMBL29123536	0.89	MAPK1 (0.42)	MAPTSCN9AFFAR1HDAC1HDAC6
SCHEMBL24664167	0.89	MAPK1 (0.42)	MAPTSCN9AFFAR1HDAC1HDAC6
SCHEMBL24665367	0.89	LTA4H (0.38)	LTA4HMAPTFFAR1THRBPKM
SCHEMBL30006150	0.89	LTA4H (0.38)	LTA4HMAPTFFAR1THRBPKM
SCHEMBL24665374	0.86	PTPN1 (0.39)	MAPTSCN9AFFAR1GRNSORT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022219546-A1	HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H	NOVARTIS AG (CH)	2022-10-20	—	—	WO	disclosed