SCHEMBL2466664

SCHEMBL2466664

[c]1ccc(C2CCC(N3CCOCC3)CC2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 2/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2D6 P10635 1/20 0.46
CYP2C19 P33261 1/20 0.46
HPGD P15428 1/20 0.45
KMT2A Q03164 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
IRAK4 Q9NWZ3 6/20 0.44
KDM1A O60341 1/20 0.43
MAOB P27338 1/20 0.43
SLC18A3 Q16572 1/20 0.41
L3MBTL3 Q96JM7 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
ABL1 P00519 1/20 0.41
LCK P06239 1/20 0.41
LYN P07948 1/20 0.41
MET P08581 1/20 0.41
PDGFRB P09619 1/20 0.41
KIT P10721 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28523429 0.90 SLC6A4 (0.46) HRH3CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL27709432 0.84 CYP2D6 (0.65) HRH3CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL10836464 0.81 HRH3 (0.52) HRH3CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL2874610 0.81 HRH3 (0.52) HRH3CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL2876268 0.81 HRH3 (0.52) HRH3CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL519944 0.81 HRH3 (0.52) HRH3CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL4612961 0.81 L3MBTL3 (0.56) HRH3L3MBTL3L3MBTL1OPRL1
SCHEMBL2383142 0.79 KCNH2 (0.37) HRH3CYP3A4CYP2C9SMN1; SMN2SLC18A3
SCHEMBL1443782 0.78 HRH3 (0.49) HRH3CYP3A4CYP2C9CYP2D6CYP2C19
SCHEMBL28770195 0.77 HRH3 (0.44) HRH3CYP3A4CYP2C9CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2545047-A1 HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) Probiodrug AG (DE) 2013-01-16 EP disclosed
WO-2011110613-A1 HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) PROBIODRUG AG (DE) 2011-09-15 WO disclosed