Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2466664 | 0.90 | HRH3 (0.50) | SLC6A4HRH3CYP3A4CYP2C9KDM1A | |
| SCHEMBL4612961 | 0.75 | L3MBTL3 (0.56) | HRH3L3MBTL3L3MBTL1OPRL1 | |
| SCHEMBL27709432 | 0.75 | CYP2D6 (0.65) | HRH3CYP3A4CYP2C9KDM1AMAOB | |
| SCHEMBL2383142 | 0.73 | KCNH2 (0.37) | HRH3CYP3A4CYP2C9KCNH2SMN1; SMN2 | |
| SCHEMBL2874610 | 0.72 | HRH3 (0.52) | HRH3CYP3A4CYP2C9KDM1AMAOB | |
| SCHEMBL10836464 | 0.72 | HRH3 (0.52) | HRH3CYP3A4CYP2C9IRAK4CYP2D6 | |
| SCHEMBL2876268 | 0.72 | HRH3 (0.52) | HRH3CYP3A4CYP2C9KDM1AMAOB | |
| SCHEMBL519944 | 0.72 | HRH3 (0.52) | HRH3CYP3A4CYP2C9KDM1AMAOB | |
| SCHEMBL28770195 | 0.69 | HRH3 (0.44) | HRH3CYP3A4CYP2C9KDM1AMAOB | |
| SCHEMBL10306270 | 0.69 | SLC6A4 (0.50) | SLC6A4PRCPKCNH2IRAK4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112368285-A | Pyrrolotriazine compounds and methods of inhibiting TAM kinase | 希洛斯医药品股份有限公司 | 2021-02-12 | — | — | CN | disclosed |