Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 5/20 | 0.34 |
| ▸ | ABL1 | P00519 | 4/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24669161 | 0.84 | HTT (0.52) | CCNE1CDK2HTTSRCABL1 | |
| SCHEMBL2554057 | 0.78 | PPARG (0.51) | CA1CA2CA7CA13HTT | |
| SCHEMBL4712462 | 0.76 | HTT (0.51) | CA1CA2CA7CA13CCNE1 | |
| SCHEMBL24670415 | 0.75 | CA1 (0.42) | CA1CA2CA7CA13CCNE1 | |
| SCHEMBL24670075 | 0.74 | CA1 (0.39) | CA1CA2CA7CA13CCNE1 | |
| SCHEMBL14914225 | 0.71 | PPARG (0.53) | CA1CA2CA7CA13HTT | |
| SCHEMBL24670094 | 0.71 | CA1 (0.49) | CA1CA2CA7CA13HTT | |
| SCHEMBL24669164 | 0.69 | CDK4 (0.42) | CCNE1CDK2SRC | |
| SCHEMBL24669593 | 0.69 | HTT (0.43) | CA1CA2CA7CA13CCNE1 | |
| SCHEMBL1521840 | 0.69 | ALDH1A1 (0.40) | CA1CA2CA7CA13HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |