SCHEMBL2466950

SCHEMBL2466950

Cc1ccccc1-c1ccc(NC(=O)O)c([N+](=O)[O-])c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 6/20 0.52
ABCC1 P33527 5/20 0.52
KCNMA1 Q12791 2/20 0.52
ALDH1A1 P00352 4/20 0.50
NPC1 O15118 3/20 0.48
RAB9A P51151 3/20 0.48
MAPK1 P28482 2/20 0.48
GLA P06280 1/20 0.48
CASP3 P42574 1/20 0.48
HTT P42858 1/20 0.48
SENP8 Q96LD8 1/20 0.48
SENP7 Q9BQF6 1/20 0.48
SENP6 Q9GZR1 1/20 0.48
HCAR3 P49019 1/20 0.48
MAPT P10636 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
MEN1 O00255 1/20 0.46
POLB P06746 1/20 0.46
KMT2A Q03164 1/20 0.46
APP P05067 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17457463 0.84 ABCB1 (0.69) ABCB1ABCC1KCNMA1ALDH1A1NPC1
SCHEMBL17457465 0.84 ABCB1 (0.69) ABCB1ABCC1KCNMA1ALDH1A1NPC1
SCHEMBL2135471 0.84 ABCB1 (0.45) ABCB1ABCC1KCNMA1ALDH1A1NPC1
SCHEMBL7464046 0.83 MAPT (0.49) ABCB1ABCC1KCNMA1ALDH1A1MAPK1
SCHEMBL12117513 0.79 HSD17B10 (0.58) ALDH1A1NPC1RAB9AMAPK1MAPT
SCHEMBL13309518 0.79 ALDH1A1 (0.59) ALDH1A1MAPTSMN1; SMN2
SCHEMBL3270267 0.78 S1PR1 (0.56) ALDH1A1MAPK1MAPTSMN1; SMN2MEN1
SCHEMBL12117470 0.77 SLC6A3 (0.47) ABCB1ALDH1A1NPC1RAB9AMAPK1
SCHEMBL2470223 0.77 HDAC1 (0.53) ABCB1ABCC1ALDH1A1MAPT
SCHEMBL1704376 0.76 ALDH1A1 (0.71) KCNMA1ALDH1A1NPC1RAB9AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2367599-A1 INHIBITION OF HDAC2 TO PROMOTE MEMORY Massachusetts Institute of Technology (US) 2011-09-28 EP disclosed
WO-2010065117-A1 INHIBITION OF HDAC2 TO PROMOTE MEMORY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2010-06-10 WO disclosed
EP-1224175-A2 BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2002-07-24 EP disclosed
WO-2001029012-A2 BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2001-04-26 WO disclosed