Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 8/20 | 0.51 |
| ▸ | CA2 | P00918 | 8/20 | 0.51 |
| ▸ | CA9 | Q16790 | 8/20 | 0.51 |
| ▸ | CA12 | O43570 | 7/20 | 0.51 |
| ▸ | CA7 | P43166 | 7/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3060695 | 0.85 | CA12 (0.68) | HPGDCA1CA2CA9CA12 | |
| SCHEMBL8358137 | 0.84 | SIGMAR1 (0.81) | SIGMAR1HPGDMKNK1MKNK2ALDH1A1 | |
| SCHEMBL15566282 | 0.84 | SIGMAR1 (0.60) | SIGMAR1HPGDMKNK1MKNK2CA1 | |
| SCHEMBL1256167 | 0.80 | SIGMAR1 (0.68) | SIGMAR1HPGDCA1CA2CA9 | |
| SCHEMBL3583338 | 0.79 | HPGD (0.73) | SIGMAR1HPGDMKNK1MKNK2CA1 | |
| SCHEMBL8260488 | 0.79 | SIGMAR1 (0.72) | SIGMAR1HPGDMKNK1MKNK2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10901857 | 0.78 | SIGMAR1 (0.66) | SIGMAR1HPGDCA1CA2CA9 | |
| SCHEMBL5273 | 0.78 | SIGMAR1 (0.70) | SIGMAR1HPGDMKNK1MKNK2LMNA | |
| SCHEMBL23140495 | 0.78 | SIGMAR1 (0.76) | SIGMAR1HPGDMKNK1MKNK2ALDH1A1 | |
| SCHEMBL4505138 | 0.78 | SIGMAR1 (0.70) | SIGMAR1HPGDMKNK1MKNK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |