Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.72 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CCNC | P24863 | 5/20 | 0.58 |
| ▸ | CDK8 | P49336 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | TDO2 | P48775 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.53 |
| ▸ | GABRD | O14764 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358137 | 0.94 | SIGMAR1 (0.81) | SIGMAR1MKNK1MKNK2HPGDL3MBTL1 | |
| SCHEMBL5266293 | 0.93 | SIGMAR1 (0.80) | SIGMAR1MKNK1MKNK2HPGDMAPK1 | |
| SCHEMBL8934929 | 0.93 | SIGMAR1 (0.64) | SIGMAR1MKNK1MKNK2HPGDMAPK1 | |
| SCHEMBL29800584 | 0.91 | SIGMAR1 (0.62) | SIGMAR1MKNK1MKNK2HPGDMAPK1 | |
| Hydrochloric Acid SCHEMBL4763940 | 0.91 | SIGMAR1 (0.77) | SIGMAR1MKNK1MKNK2HPGDMAPK1 | |
| SCHEMBL16574186 | 0.91 | GABRD (0.66) | SIGMAR1MKNK1MKNK2HPGDMAPK1 | |
| SCHEMBL7425708 | 0.90 | MKNK1 (0.72) | SIGMAR1MKNK1MKNK2HPGDMAPK1 | |
| SCHEMBL3583338 | 0.88 | HPGD (0.73) | SIGMAR1MKNK1MKNK2HPGDMAPK1 | |
| SCHEMBL23140495 | 0.86 | SIGMAR1 (0.76) | SIGMAR1MKNK1MKNK2HPGDMAPK1 | |
| SCHEMBL4505138 | 0.86 | SIGMAR1 (0.70) | SIGMAR1MKNK1MKNK2HPGDCCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111795-A1 | Multimers of Heterocyclic Compounds and Their Use | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-30 | — | — | US | disclosed |
| US-20090111795-A1 | Multimers of Heterocyclic Compounds and Their Use | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-30 | — | — | US | disclosed |
| US-20090105268-A1 | Dihydropyrimidone Multimers and Their Use as Human Neutrophil, Elastase Inhibitors | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-23 | — | — | US | disclosed |
| US-20090105268-A1 | Dihydropyrimidone Multimers and Their Use as Human Neutrophil, Elastase Inhibitors | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-23 | — | — | US | disclosed |
| WO-2006082412-A2 | MULTIMERS OF PYRIMIDINONE DERIVATIVES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | ARGENTA DISCOVERY LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105268-A1 | Dihydropyrimidone Multimers and Their Use as Human Neutrophil, Elastase Inhibitors | SERPINB1, ELANE, MPO | SIGMAR1 4501/4885MKNK1 1719/4885MKNK2 1947/4885 |
| US-20090111795-A1 | Multimers of Heterocyclic Compounds and Their Use | MRM1, ME2, SDHA | SIGMAR1 3625/4885MKNK1 2456/4885MKNK2 2614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.