Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 6/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23200538 | 0.85 | ALDH1A1 (0.42) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL7754930 | 0.81 | PTGS2 (0.39) | KDM4EPTGS2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10451439 | 0.79 | RAB9A (0.39) | KDM4EPTGS2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10451438 | 0.79 | ALDH1A1 (0.38) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL939715 | 0.77 | ALDH1A1 (0.55) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL18231235 | 0.77 | CA1 (0.43) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL31391620 | 0.77 | CA1 (0.41) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL10688788 | 0.77 | CA12 (0.50) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL1127112 | 0.75 | PTGES2 (0.49) | CA12CA1CA2CA9PTGS2 | |
| SCHEMBL29721599 | 0.75 | PTGES2 (0.49) | CA12CA1CA2CA9PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |