SCHEMBL24670221

SCHEMBL24670221

COc1cc(C2=CCNCC2)ccc1NC(=O)c1ccc(C2=CCNCC2)c(F)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
QDPR P09417 1/20 0.51
ALDH1A1 P00352 2/20 0.47
HPGD P15428 2/20 0.47
KDM4E B2RXH2 1/20 0.47
MAPT P10636 1/20 0.47
CCNT1 O60563 4/20 0.46
CDK9 P50750 4/20 0.46
BRPF1 P55201 1/20 0.46
TAS1R3 Q7RTX0 1/20 0.44
TAS1R1 Q7RTX1 1/20 0.44
TAS1R2 Q8TE23 1/20 0.44
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
CD274 Q9NZQ7 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C19 P33261 1/20 0.42
TGFBR1 P36897 1/20 0.42
ACVR1 Q04771 1/20 0.42
KCNH2 Q12809 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29803895 1.00 QDPR (0.51) QDPRALDH1A1HPGDKDM4EMAPT
SCHEMBL24669304 0.87 CCNT1 (0.47) QDPRCCNT1CDK9BRPF1CSF1R
SCHEMBL29803667 0.87 CCNT1 (0.47) QDPRCCNT1CDK9BRPF1CSF1R
SCHEMBL29803697 0.85 BRPF1 (0.49) QDPRCCNT1CDK9BRPF1TAS1R3
SCHEMBL24670849 0.85 BRPF1 (0.49) QDPRCCNT1CDK9BRPF1TAS1R3
SCHEMBL29803753 0.85 CCNT1 (0.45) QDPRKDM4ECCNT1CDK9CSF1R
SCHEMBL29803524 0.84 CCNT1 (0.49) QDPRALDH1A1KDM4EMAPTCCNT1
SCHEMBL29803346 0.82 NAMPT (0.51) QDPRCCNT1CDK9
Trifluoroacetic Acid SCHEMBL29803514 0.82 CCNT1 (0.43) QDPRCCNT1CDK9BRPF1CSF1R
SCHEMBL29803563 0.81 CCNT1 (0.48) CCNT1CDK9BRPF1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed