SCHEMBL24670849

SCHEMBL24670849

COc1cc(NC(=O)c2ccc(C3=CCNCC3)c(F)c2)c(C)cc1C1=CCNCC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRPF1 P55201 1/20 0.49
CCNT1 O60563 8/20 0.47
CDK9 P50750 8/20 0.47
CD274 Q9NZQ7 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C19 P33261 1/20 0.40
BTK Q06187 1/20 0.40
QDPR P09417 1/20 0.39
EHMT2 Q96KQ7 1/20 0.38
EHMT1 Q9H9B1 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38
TAS1R2 Q8TE23 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29803697 1.00 BRPF1 (0.49) BRPF1CCNT1CDK9CD274MEN1
SCHEMBL29803370 0.91 CCNT1 (0.49) BRPF1CCNT1CDK9BTKNPC1
Trifluoroacetic Acid SCHEMBL29803416 0.85 CCNT1 (0.45) BRPF1CCNT1CDK9BTKWDR5
SCHEMBL29803895 0.85 QDPR (0.51) BRPF1CCNT1CDK9CD274MEN1
SCHEMBL24670221 0.85 QDPR (0.51) BRPF1CCNT1CDK9CD274MEN1
SCHEMBL29803524 0.85 CCNT1 (0.49) BRPF1CCNT1CDK9QDPRSMN1; SMN2
SCHEMBL24669304 0.84 CCNT1 (0.47) BRPF1CCNT1CDK9BTKQDPR
SCHEMBL29803667 0.84 CCNT1 (0.47) BRPF1CCNT1CDK9BTKQDPR
SCHEMBL29803772 0.83 BTK (0.45) BRPF1CCNT1CDK9BTKQDPR
SCHEMBL24671378 0.82 WDR5 (0.43) BRPF1CCNT1CDK9BTKWDR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed