SCHEMBL24670313

SCHEMBL24670313

Cc1cc(C2=CCN(C(=O)OC(C)(C)C)CC2)c(F)cc1NC(=O)c1ccc(C2=CCN(C(=O)OC(C)(C)C)CC2)cc1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 1/20 0.49
WDR5 P61964 2/20 0.48
JAK1 P23458 1/20 0.46
PDK4 Q16654 1/20 0.46
SCN9A Q15858 1/20 0.45
GRM5 P41594 6/20 0.45
GRM1 Q13255 6/20 0.45
CDK7 P50613 1/20 0.43
CDK13 Q14004 1/20 0.43
CDK12 Q9NYV4 1/20 0.43
CDK9 P50750 3/20 0.43
CCNT1 O60563 1/20 0.43
KMT2A Q03164 1/20 0.41
WNT3A P56704 1/20 0.41
SOS1 Q07889 1/20 0.41
HTR6 P50406 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24669316 0.93 WDR5 (0.48) NAMPTWDR5JAK1PDK4SCN9A
SCHEMBL29803452 0.93 WDR5 (0.48) NAMPTWDR5JAK1PDK4SCN9A
SCHEMBL24671112 0.90 WDR5 (0.49) NAMPTWDR5JAK1PDK4GRM5
SCHEMBL24670170 0.90 WDR5 (0.53) NAMPTWDR5JAK1PDK4SCN9A
SCHEMBL29803388 0.90 WDR5 (0.53) NAMPTWDR5JAK1PDK4SCN9A
SCHEMBL29803675 0.89 CDK9 (0.47) NAMPTWDR5JAK1PDK4GRM5
SCHEMBL24670342 0.89 CDK9 (0.47) NAMPTWDR5JAK1PDK4GRM5
SCHEMBL24670616 0.89 NAMPT (0.49) NAMPTWDR5JAK1PDK4SCN9A
SCHEMBL24670980 0.88 WNT3A (0.48) WDR5JAK1PDK4SCN9AGRM5
SCHEMBL24669298 0.88 WDR5 (0.48) NAMPTWDR5JAK1PDK4SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed