SCHEMBL24670541

SCHEMBL24670541

CN(C(=O)c1ccc(N2CCNCC2)cc1)c1ccc(N2CCNCC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 3/20 0.57
ALDH1A1 P00352 3/20 0.55
TSHR P16473 2/20 0.55
USP2 O75604 1/20 0.55
HSD17B10 Q99714 1/20 0.55
ADRB1 P08588 5/20 0.49
MAOB P27338 2/20 0.46
ACVR1 Q04771 1/20 0.45
HTR3E A5X5Y0 3/20 0.45
HTR3B O95264 3/20 0.45
HTR3A P46098 3/20 0.45
HTR3D Q70Z44 3/20 0.45
HTR3C Q8WXA8 3/20 0.45
SIGMAR1 Q99720 3/20 0.45
HIF1A Q16665 1/20 0.44
EPAS1 Q99814 1/20 0.44
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
CYP2D6 P10635 1/20 0.43
CLK4 Q9HAZ1 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5235537 0.86 ALDH1A1 (0.59) MAPKAPK2ALDH1A1TSHRUSP2HSD17B10
SCHEMBL8664194 0.86 ITGB3 (0.53) MAPKAPK2ALDH1A1TSHRUSP2HSD17B10
Hydrochloric Acid SCHEMBL31349246 0.84 ALDH1A1 (0.58) MAPKAPK2ALDH1A1TSHRUSP2HSD17B10
SCHEMBL3246144 0.84 MAPKAPK2 (0.53) MAPKAPK2ALDH1A1TSHRUSP2HSD17B10
SCHEMBL5235280 0.81 TSHR (0.54) ALDH1A1TSHRUSP2HSD17B10ADRB1
SCHEMBL14327022 0.81 ALDH1A1 (0.54) MAPKAPK2ALDH1A1TSHRUSP2HSD17B10
SCHEMBL29803082 0.77 CHIA (0.52) ALDH1A1USP2HSD17B10HIF1AEPAS1
SCHEMBL232986 0.77 ALDH1A1 (0.65) ALDH1A1TSHRUSP2HSD17B10ADRB1
SCHEMBL6094124 0.77 ALDH1A1 (0.65) ALDH1A1TSHRUSP2HSD17B10ADRB1
SCHEMBL2427902 0.77 ALDH1A1 (0.86) ALDH1A1TSHRUSP2HSD17B10ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed