SCHEMBL24670907

SCHEMBL24670907

Cc1cc(C2=CCNCC2)cc(F)c1C(=O)NC(C)C

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 2/20 0.38
CDK9 P50750 2/20 0.38
QDPR P09417 3/20 0.38
SCN9A Q15858 1/20 0.37
HTR2C P28335 4/20 0.37
FTO Q9C0B1 1/20 0.36
CD274 Q9NZQ7 1/20 0.36
SIGMAR1 Q99720 2/20 0.35
CTSL P07711 1/20 0.35
CTSB P07858 1/20 0.35
CTSS P25774 1/20 0.35
CTSK P43235 1/20 0.35
HTR6 P50406 1/20 0.35
NAMPT P43490 1/20 0.34
PRMT5 O14744 1/20 0.34
MAPKAPK2 P49137 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24670321 0.79 QDPR (0.47) CCNT1CDK9QDPRHTR2CFTO
SCHEMBL29803843 0.78 MAPKAPK2 (0.40) CCNT1CDK9QDPRHTR2CFTO
Hydrochloric Acid SCHEMBL29803628 0.78 MAPKAPK2 (0.40) CCNT1CDK9QDPRHTR2CFTO
SCHEMBL904201 0.74 HTR2C (0.49) QDPRHTR2CCD274SIGMAR1HTR6
SCHEMBL24670925 0.74 CCNT1 (0.41) CCNT1CDK9CD274HTR6PRMT5
SCHEMBL29803537 0.73 MAPKAPK2 (0.41) CCNT1CDK9QDPRHTR2CCD274
SCHEMBL24670266 0.73 CCNT1 (0.52) CCNT1CDK9HTR6PRMT5
SCHEMBL10067587 0.69 QDPR (0.58) QDPRSCN9AHTR2CSIGMAR1
Trifluoroacetic Acid SCHEMBL29803779 0.69 MAPKAPK2 (0.38) CCNT1CDK9HTR2CFTOCD274
SCHEMBL24670935 0.69 CCNT1 (0.39) CCNT1CDK9QDPRHTR2CSIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed