Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | QDPR | P09417 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670817 | 0.81 | SIGMAR1 (0.57) | HTR2CSIGMAR1QDPRHTR2AHTR7 | |
| SCHEMBL16434840 | 0.81 | HTR2C (0.57) | HTR2CSIGMAR1QDPRHTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL16422718 | 0.79 | HTR2C (0.58) | HTR2CSIGMAR1QDPRHTR2AHTR7 | |
| SCHEMBL10067587 | 0.78 | QDPR (0.58) | HTR2CSIGMAR1QDPR | |
| SCHEMBL3386020 | 0.77 | SIGMAR1 (0.59) | HTR2CSIGMAR1QDPRHTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL28669700 | 0.75 | HTR2C (0.60) | HTR2CSIGMAR1QDPRHTR2AHTR7 | |
| SCHEMBL5319444 | 0.75 | SIGMAR1 (0.57) | HTR2CSIGMAR1QDPRHTR2AHTR6 | |
| SCHEMBL14956908 | 0.75 | QDPR (0.60) | HTR2CSIGMAR1QDPRHTR7HTR6 | |
| SCHEMBL3383939 | 0.75 | HTR2C (0.62) | HTR2CSIGMAR1QDPRHTR2AHTR7 | |
| SCHEMBL5319876 | 0.74 | SIGMAR1 (0.47) | HTR2CSIGMAR1QDPRHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |