Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670999 | 0.79 | ALDH1A1 (0.46) | TSHRRAB9AMAPK1NPC1TP53 | |
| SCHEMBL4525253 | 0.78 | ALDH1A1 (0.50) | HTTTSHRRAB9AMAPK1NPC1 | |
| SCHEMBL24671004 | 0.77 | MEN1 (0.51) | RAB9AMAPK1NPC1TP53KDM4E | |
| SCHEMBL17653864 | 0.75 | ALDH1A1 (0.47) | HTTTSHRRAB9AMAPK1NPC1 | |
| SCHEMBL3660419 | 0.74 | HTT (0.56) | HTTMAPK1S1PR1ALDH1A1L3MBTL1 | |
| SCHEMBL4169984 | 0.74 | CCR6 (0.57) | HTTMAPK1CCR6PAX8ALDH1A1 | |
| SCHEMBL7378770 | 0.73 | CA1 (0.58) | HTTMAPK1S1PR1ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL27352426 | 0.73 | CCR6 (0.56) | HTTMAPK1CCR6PAX8ALDH1A1 | |
| SCHEMBL17653873 | 0.72 | RAB9A (0.49) | TSHRRAB9AMAPK1NPC1TP53 | |
| SCHEMBL2224632 | 0.71 | MEN1 (0.64) | S1PR1ALDH1A1GAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |