Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.40 |
| ▸ | WDR5 | P61964 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24671289 | 1.00 | NAMPT (0.40) | NAMPTWDR5THRBPRMT5WDR77 | |
| SCHEMBL29803446 | 1.00 | NAMPT (0.40) | NAMPTWDR5THRBPRMT5WDR77 | |
| SCHEMBL24670952 | 0.94 | NAMPT (0.41) | NAMPTWDR5PRMT5WDR77MAPT | |
| SCHEMBL24670949 | 0.94 | NAMPT (0.41) | NAMPTWDR5PRMT5WDR77MAPT | |
| SCHEMBL29803599 | 0.93 | NAMPT (0.41) | NAMPTPRMT5WDR77MAPTTRPV1 | |
| SCHEMBL24670309 | 0.91 | WDR5 (0.41) | NAMPTWDR5TRPV1SOS1 | |
| SCHEMBL29803297 | 0.91 | WDR5 (0.41) | NAMPTWDR5TRPV1SOS1 | |
| SCHEMBL24670301 | 0.91 | NAMPT (0.39) | NAMPTWDR5PRMT5WDR77MAPT | |
| SCHEMBL24670307 | 0.91 | WDR5 (0.41) | NAMPTWDR5TRPV1SOS1 | |
| SCHEMBL24671366 | 0.91 | NAMPT (0.39) | NAMPTTHRBMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022192162-A1 | NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE | FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) | 2022-09-15 | — | — | WO | disclosed |