SCHEMBL24671378

SCHEMBL24671378

Cc1cc(C2=CCNCC2)c(F)cc1NC(=O)c1ccc(C2=CCN(C)CC2)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
WDR5 P61964 3/20 0.43
CCNT1 O60563 4/20 0.43
CDK9 P50750 4/20 0.43
BRPF1 P55201 1/20 0.40
BTK Q06187 1/20 0.38
NOS3 P29474 2/20 0.35
NOS1 P29475 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29803370 0.91 CCNT1 (0.49) WDR5CCNT1CDK9BRPF1BTK
SCHEMBL24671371 0.87 CCNT1 (0.45) WDR5CCNT1CDK9NOS3NOS1
SCHEMBL24669341 0.87 CCNT1 (0.45) WDR5CCNT1CDK9NOS3NOS1
Trifluoroacetic Acid SCHEMBL29803416 0.85 CCNT1 (0.45) WDR5CCNT1CDK9BRPF1BTK
SCHEMBL24670037 0.83 CCNT1 (0.42) WDR5CCNT1CDK9NOS3NOS1
SCHEMBL24669975 0.83 WDR5 (0.46) WDR5CCNT1CDK9BRPF1BTK
SCHEMBL29803772 0.83 BTK (0.45) WDR5CCNT1CDK9BRPF1BTK
SCHEMBL29803697 0.82 BRPF1 (0.49) WDR5CCNT1CDK9BRPF1BTK
SCHEMBL24670849 0.82 BRPF1 (0.49) WDR5CCNT1CDK9BRPF1BTK
SCHEMBL24671471 0.82 CSF1R (0.40) BRPF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed