Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TET3 | O43151 | 2/20 | 0.47 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.47 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.47 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.47 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467179 | 1.00 | ALDH1A1 (0.58) | ALDH1A1OPRL1OPRM1ERCC1ERCC4 | |
| SCHEMBL2468363 | 0.92 | CHRM5 (0.58) | ALDH1A1OPRL1OPRM1KMT2ATET3 | |
| SCHEMBL2468362 | 0.92 | CHRM5 (0.58) | ALDH1A1OPRL1OPRM1KMT2ATET3 | |
| SCHEMBL13182939 | 0.88 | ALDH1A1 (0.45) | ALDH1A1OPRL1OPRM1ERCC1ERCC4 | |
| SCHEMBL2473530 | 0.88 | CHRM5 (0.53) | ALDH1A1OPRL1OPRM1KMT2ATET3 | |
| SCHEMBL13182920 | 0.88 | CHRM5 (0.53) | ALDH1A1OPRL1OPRM1KMT2ATET3 | |
| SCHEMBL2468360 | 0.85 | GRIN2B (0.48) | ALDH1A1OPRL1KMT2AOPRD1KCNH2 | |
| SCHEMBL2468358 | 0.85 | GRIN2B (0.48) | ALDH1A1OPRL1KMT2AOPRD1KCNH2 | |
| SCHEMBL10253720 | 0.81 | CHRM5 (0.48) | OPRL1OPRM1KMT2ATET3FBXL19 | |
| SCHEMBL2473441 | 0.81 | CHRM5 (0.48) | OPRL1OPRM1KMT2ATET3FBXL19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2228065-B1 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB CO (US) | 2012-12-26 | — | — | EP | claimed |
| EP-2228065-B1 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB CO (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-1501467-B1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-2371366-A1 | Heterocyclo inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| EP-2228065-A2 | Heterocyclo inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2010-09-15 | — | — | EP | disclosed |
| US-20090312307-A1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY | 2009-12-17 | — | — | US | disclosed |
| US-7582654-B2 | Heterocyclo inhibitors of potassium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-01 | — | — | US | disclosed |
| US-7005436-B2 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB COMPANY (US) | 2006-02-28 | — | — | US | disclosed |
| US-20060014792-A1 | Heterocyclo inhibitors of potassium channel function | LLOYD JOHN | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014792-A1 | Heterocyclo inhibitors of potassium channel function | KCNJ2, KCNH2, KCNQ5 | ALDH1A1 3941/4885OPRL1 1904/4885OPRM1 2850/4885 |
| US-20090312307-A1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | KCNJ2, KCNH2, KCNQ5 | ALDH1A1 3941/4885OPRL1 1904/4885OPRM1 2850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.