SCHEMBL1085687

SCHEMBL1085687

COc1ncnc2[nH]ccc12

nearest known ligand 0.60

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 5/20 0.60
JAK3 P52333 4/20 0.55
TTBK1 Q5TCY1 6/20 0.54
TTBK2 Q6IQ55 6/20 0.54
MKNK1 Q9BUB5 1/20 0.54
MKNK2 Q9HBH9 1/20 0.54
BRD4 O60885 1/20 0.53
JAK2 O60674 1/20 0.47
TNNI3K Q59H18 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1086048 0.81 TTBK1 (0.60) TRPA1JAK3TTBK1TTBK2BRD4
SCHEMBL2540294 0.81 TRPA1 (0.53) TRPA1JAK3TTBK1TTBK2MKNK1
SCHEMBL12561811 0.78 TRPA1 (0.53) TRPA1JAK3TTBK1TTBK2JAK2
SCHEMBL21262326 0.76 TRPA1 (0.51) TRPA1JAK3TTBK1TTBK2BRD4
SCHEMBL18680737 0.76 TRPA1 (0.51) TRPA1JAK3TTBK1TTBK2MKNK1
SCHEMBL16912583 0.75 TRPA1 (0.50) TRPA1JAK3TTBK1TTBK2TNNI3K
SCHEMBL22569504 0.75 TRPA1 (0.50) TRPA1JAK3TTBK1TTBK2BRD4
SCHEMBL24671871 0.74 ENPP1 (0.42)
SCHEMBL22508755 0.74 TTBK1 (0.59) TTBK1TTBK2MKNK1MKNK2
SCHEMBL7958023 0.74 HRH4 (0.45) TRPA1TTBK1TTBK2MKNK1MKNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4739671-A1 NEW COMPOUNDS Aston University (GB) 2026-05-13 EP disclosed
US-20250302995-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF SHIVALILA CHIKDU SHAKTI (US) 2025-10-02 US disclosed
US-20250262235-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO WAVE LIFE SCIENCES LTD (SG) 2025-08-21 US disclosed
CN-120118141-A Nucleoside analogues and uses thereof 广州市恒诺康医药科技有限公司 2025-06-10 CN disclosed
US-20250136606-A1 MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE CARAWAY THERAPEUTICS, INC. (US) 2025-05-01 US disclosed
US-20250135036-A1 COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2025-05-01 US disclosed
EP-4522744-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF Wave Life Sciences Ltd. (SG) 2025-03-19 EP disclosed
EP-4507700-A2 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO Wave Life Sciences Ltd. (SG) 2025-02-19 EP disclosed
CN-119452084-A Oligonucleotide compositions and methods thereof 波涛生命科学有限公司 2025-02-14 CN disclosed
US-20250041319-A1 BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS RIBOSCIENCE LLC 2025-02-06 US disclosed
US-20090286783-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. 2009-11-19 US disclosed
US-20090286783-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. 2009-11-19 US disclosed
US-20090286782-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. 2009-11-19 US disclosed
US-20090286782-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. 2009-11-19 US disclosed
US-20090286782-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. 2009-11-19 US disclosed
US-20090286783-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON, INC. 2009-11-19 US disclosed
US-7259154-B2 Anticancer agents; asthma; rhintis; vision disorders; skin disorders; antiarthritic agents; antiinflammatory agents; antiallergens AVENTIS PHARMACEUTICALS INC. (US) 2007-08-21 US disclosed
US-20040142947-A1 Pyrrolopyrimidines AVENTIS PHARMACEUTICALS, INC. 2004-07-22 US disclosed
EP-1404676-A1 PYRROLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2004-04-07 EP disclosed
WO-2003000695-A1 PYRROLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS AVENTIS PHARMACEUTICALS INC (US) 2003-01-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286783-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR BRAF, PRKACA, RAF1 TRPA1 574/4885JAK3 127/4885TTBK1 325/4885
US-20250302995-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF ADAR, NSUN2, RNGTT TRPA1 3949/4885JAK3 1512/4885TTBK1 4154/4885
US-20250262235-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO ADAR, RNGTT, NSUN2 TRPA1 4881/4885JAK3 2629/4885TTBK1 4097/4885
US-20090286782-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PRKDC, PRKACA, PRKACG TRPA1 3284/4885JAK3 61/4885TTBK1 1366/4885
US-20250135036-A1 COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF MECP2, ADAR, NSUN2 TRPA1 4524/4885JAK3 2321/4885TTBK1 2901/4885
US-20250041319-A1 BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS ENPP1, ENPP3, SMPD1 TRPA1 4787/4885JAK3 4175/4885TTBK1 2853/4885
US-20250136606-A1 MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE MCOLN1, TRPM2, PKD2 TRPA1 30/4885JAK3 4405/4885TTBK1 434/4885
US-20040142947-A1 Pyrrolopyrimidines DPYD, TYMP, PNPO TRPA1 4633/4885JAK3 2850/4885TTBK1 2547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.