Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9888383 | 0.73 | ABL1 (0.38) | ABL1RIN1MAP2K1PIM1PARP1 | |
| SCHEMBL8515018 | 0.72 | NOTUM (0.54) | NOTUMMAP2K1PIM1GCKBTK | |
| SCHEMBL24896854 | 0.72 | BTK (0.54) | NOTUMMAP2K1PIM1BTKCYP3A4 | |
| SCHEMBL3451431 | 0.72 | XDH (0.49) | NOTUMABL1RIN1GSK3BXDH | |
| SCHEMBL3042222 | 0.72 | CHEK1 (0.49) | NOTUMGSK3BCDK5BTKXDH | |
| SCHEMBL29465036 | 0.71 | KDM4A (0.45) | NOTUMPIM1 | |
| SCHEMBL8535240 | 0.71 | NOTUM (0.68) | NOTUMMAP2K1PIM1GCKNPY5R | |
| SCHEMBL5709792 | 0.70 | NOTUM (0.52) | NOTUMGSK3BCDK5BTKNPY5R | |
| Hydrochloric Acid SCHEMBL29856925 | 0.70 | XDH (0.47) | NOTUMABL1RIN1GSK3BXDH | |
| SCHEMBL29664837 | 0.70 | NOTUM (0.52) | NOTUMGSK3BCDK5BTKNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340576-A1 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2022-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340576-A1 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | PTPRCAP, PTPN22, PTPN1 | NOTUM 4201/4885ABL1 56/4885RIN1 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.