Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.51 |
| ▸ | CDC7 | O00311 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | CDK9 | P50750 | 3/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CDK8 | P49336 | 3/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.51 |
| ▸ | PIM1 | P11309 | 3/20 | 0.51 |
| ▸ | PRKACA | P17612 | 3/20 | 0.51 |
| ▸ | GSK3B | P49841 | 3/20 | 0.51 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | CLK2 | P49760 | 2/20 | 0.51 |
| ▸ | CDK7 | P50613 | 2/20 | 0.51 |
| ▸ | PRKX | P51817 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24672397 | 0.80 | CDK9 (0.57) | ROCK2ROCK1LRRK2CDC7CDK2 | |
| SCHEMBL23883560 | 0.79 | LRRK2 (0.59) | ROCK2ROCK1LRRK2CDC7CDK2 | |
| SCHEMBL30668720 | 0.78 | ROCK2 (0.60) | ROCK2ROCK1LRRK2CDC7CDK2 | |
| SCHEMBL20744209 | 0.78 | ROCK2 (0.60) | ROCK2ROCK1LRRK2CDC7CDK2 | |
| SCHEMBL30668694 | 0.76 | CDK9 (0.61) | ROCK2ROCK1LRRK2CDC7CDK2 | |
| SCHEMBL20744107 | 0.76 | CDK9 (0.61) | ROCK2ROCK1LRRK2CDC7CDK2 | |
| SCHEMBL27729854 | 0.72 | CDK5 (0.45) | ROCK2ROCK1LRRK2CDC7CDK2 | |
| SCHEMBL20758425 | 0.72 | CDK2 (0.57) | ROCK2ROCK1LRRK2CDC7CDK2 | |
| SCHEMBL16785960 | 0.71 | LRRK2 (0.62) | ROCK2ROCK1LRRK2CDC7CDK2 | |
| SCHEMBL20846296 | 0.71 | CDK2 (0.49) | ROCK2ROCK1LRRK2CDC7CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | PDXK, CCNK, CDC42BPB | ROCK2 1115/4885ROCK1 1054/4885LRRK2 899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.