Sugi Predict

Sugi Predict / Compounds / SCHEMBL24674487

SCHEMBL24674487

SCHEMBL24674487

Cc1cnc(-c2cnc3ncnc(NCc4nc(C(F)(F)F)no4)c3c2)s1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 18/20 0.40
▸ CLK4 Q9HAZ1 5/20 0.35
▸ TDP1 Q9NUW8 2/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ CYP1A2 P05177 4/20 0.34
▸ CYP3A4 P08684 4/20 0.34
▸ HIF1A Q16665 4/20 0.34
▸ TSHR P16473 3/20 0.34
▸ CYP2D6 P10635 3/20 0.34
▸ CYP2C19 P33261 3/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ USP2 O75604 1/20 0.34
▸ APEX1 P27695 1/20 0.34
▸ CASP7 P55210 1/20 0.34
▸ CLK1 P49759 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22715145 0.89 LMNA (0.38) LMNACLK4TDP1MEN1KMT2A
SCHEMBL22714575 0.88 LMNA (0.37) LMNACLK4TDP1MEN1KMT2A
SCHEMBL22714752 0.84 PDE5A (0.36) LMNACLK4TDP1CYP1A2CYP3A4
SCHEMBL22714177 0.84 P2RX3 (0.42) LMNACLK4MEN1KMT2AP2RX3
SCHEMBL29427611 0.84 P2RX3 (0.42) LMNACLK4MEN1KMT2AP2RX3
SCHEMBL29564279 0.81 LMNA (0.38) LMNACLK4TDP1MEN1KMT2A
SCHEMBL22714286 0.81 LMNA (0.38) LMNACLK4TDP1MEN1KMT2A
SCHEMBL29564446 0.81 LMNA (0.42) LMNACLK4MEN1KMT2A
SCHEMBL22714321 0.81 LMNA (0.42) LMNACLK4MEN1KMT2A
SCHEMBL22714671 0.80 LMNA (0.37) LMNACLK4TDP1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606562-B2 Pyridopyrimidines derivatives as P2X3 inhibitors CHIESI FARMACEUTICI S.P.A. (IT) 2026-04-21 — — US disclosed
US-20230212169-A9 PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2023-07-06 — — US disclosed
US-20230212169-A9 PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2023-07-06 — — US disclosed
US-20230212169-A9 PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2023-07-06 — — US disclosed
US-20220235060-A1 PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS CHIESI FARM SPA (IT) 2022-07-28 — — US disclosed
US-20220235060-A1 PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS CHIESI FARM SPA (IT) 2022-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220235060-A1 PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS P2RX3, P2RX5, P2RX1 LMNA 3597/4885CLK4 3985/4885TDP1 1986/4885
US-12606562-B2 Pyridopyrimidines derivatives as P2X3 inhibitors P2RX3, P2RX1, P2RX2 LMNA 2712/4885CLK4 3486/4885TDP1 2161/4885
US-20230212169-A9 PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS P2RX3, P2RX5, P2RX1 LMNA 3597/4885CLK4 3985/4885TDP1 1986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.