Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2260448 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2HPGDHSD17B10ATM | |
| SCHEMBL8464443 | 0.75 | GAA (0.36) | ALDH1A1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL24802100 | 0.73 | ANPEP (0.54) | PTGS1PTGS2ALDH1A1MAPTCXCR1 | |
| SCHEMBL15181323 | 0.73 | ANPEP (0.54) | PTGS1PTGS2ALDH1A1MAPTCXCR1 | |
| SCHEMBL25071257 | 0.73 | ANPEP (0.54) | PTGS1PTGS2ALDH1A1MAPTCXCR1 | |
| SCHEMBL30313875 | 0.72 | CA12 (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL9627367 | 0.72 | CA12 (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL8460946 | 0.72 | FURIN (0.34) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL4706020 | 0.72 | C1S (0.48) | ALDH1A1MAPTKDM4EHPGDMAPK1 | |
| SCHEMBL8444352 | 0.72 | HPGD (0.50) | ALDH1A1MAPTSMN1; SMN2HPGDHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |