Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | IL1B | P01584 | 1/20 | 0.35 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MLNR | O43193 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18666649 | 0.83 | BRD4 (0.35) | BRD4TNFIL1BIKZF1DDB1 | |
| SCHEMBL21986280 | 0.81 | BRD4 (0.38) | BRD4TNFIL1BIKZF1DDB1 | |
| SCHEMBL19934106 | 0.79 | TNF (0.42) | TNFPABPC1KDM4ELMNA | |
| SCHEMBL24816670 | 0.78 | CRBN (0.33) | CRBN | |
| SCHEMBL9934296 | 0.77 | BRD4 (0.40) | BRD4TNFIL1BIKZF1DDB1 | |
| SCHEMBL22940430 | 0.75 | PAX8 (0.31) | PAX8 | |
| SCHEMBL7850519 | 0.73 | TNF (0.35) | BRD4TNFIL1BIKZF1DDB1 | |
| SCHEMBL9934235 | 0.73 | UGCG (0.39) | BRD4TNFIL1BIKZF1DDB1 | |
| SCHEMBL9935368 | 0.73 | UGCG (0.39) | BRD4TNFIL1BIKZF1DDB1 | |
| SCHEMBL7952458 | 0.73 | IDH1 (0.46) | BRD4TNFIL1BIKZF1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |