SCHEMBL24676949

SCHEMBL24676949

CNc1nc(C)c(-c2cc(NC3CCN(S(C)(=O)=O)CC3)ncc2OC)s1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 10/20 0.42
CDK4 P11802 8/20 0.42
CCND1 P24385 8/20 0.42
CDK1 P06493 8/20 0.42
CCNA2 P20248 3/20 0.42
CCND3 P30281 2/20 0.42
CDK6 Q00534 2/20 0.42
CCNT1 O60563 2/20 0.42
CDK9 P50750 2/20 0.42
CCNB1 P14635 2/20 0.42
CDK7 P50613 1/20 0.42
CCNH P51946 1/20 0.42
PI4KB Q9UBF8 4/20 0.41
P2RX3 P56373 1/20 0.41
P2RX2 Q9UBL9 1/20 0.41
DYRK1A Q13627 1/20 0.40
CCR6 P51684 1/20 0.39
PIK3CD O00329 1/20 0.39
PIK3CA P42336 1/20 0.39
TDO2 P48775 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24676947 0.87 CDK2 (0.49) CDK2CDK4CCND1CDK1CCNA2
SCHEMBL24676953 0.87 CDK2 (0.47) CDK2CDK4CCND1CDK1CCNA2
SCHEMBL24676951 0.85 CDK2 (0.47) CDK2CDK4CCND1CDK1CCNA2
SCHEMBL24676825 0.85 CCNA2 (0.43) CDK2CDK4CCND1CDK1CCNA2
SCHEMBL24676827 0.85 CDK2 (0.42) CDK2CDK4CCND1CDK1CCNA2
SCHEMBL24676948 0.80 CDK2 (0.47) CDK2CDK4CCND1CDK1CCNA2
SCHEMBL24676461 0.79 CDK2 (0.59) CDK2CDK4CCND1CDK1CCNA2
SCHEMBL24676488 0.77 CDK2 (0.48) CDK2CDK4CCND1CDK1CCNA2
SCHEMBL24676950 0.76 TDO2 (0.42) CDK2CDK4CCND1CDK1CCNA2
SCHEMBL29754970 0.73 CCR6 (0.40) CDK2CDK4CCND1CDK1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022155941-A1 CDK2 INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2022-07-28 WO disclosed