SCHEMBL24680657

SCHEMBL24680657

CC(C)(F)c1cncc(F)c1

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.38
CYP11B2 P19099 10/20 0.33
CYP11B1 P15538 9/20 0.33
CYP19A1 P11511 3/20 0.32
GRIN1 Q05586 1/20 0.31
GRIN2B Q13224 1/20 0.31
AR P10275 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30879971 1.00 HCAR2 (0.38) HCAR2CYP11B2CYP11B1CYP19A1GRIN1
SCHEMBL6371572 0.84 HCAR2 (0.39) HCAR2CYP11B2CYP11B1CYP19A1
SCHEMBL10690255 0.81 CYP11B1 (0.44) HCAR2CYP11B2CYP11B1AR
SCHEMBL19366826 0.79 GABRA1 (0.37)
SCHEMBL21958802 0.77 HCAR2 (0.38) HCAR2CYP11B2CYP11B1CYP19A1GRIN1
SCHEMBL22452947 0.77 HCAR2 (0.34) HCAR2CYP11B2CYP11B1CYP19A1
SCHEMBL19251551 0.77 HCAR2 (0.34) HCAR2CYP11B2CYP11B1CYP19A1
SCHEMBL27314830 0.76 GABRA1 (0.39) CYP11B2CYP11B1CYP19A1AR
SCHEMBL24534066 0.76 KDM4E (0.36) CYP11B2CYP11B1
SCHEMBL24534060 0.76 CYP11B1 (0.42) HCAR2CYP11B2CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240122182-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA CROP PROTECTION AG (CH) 2024-04-18 US disclosed
WO-2022157334-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA CROP PROTECTION AG (CH) 2022-07-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240122182-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS DDT, ACHE, AADAC HCAR2 4262/4885CYP11B2 2501/4885CYP11B1 2158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.