Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.40 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681355 | 0.84 | MCHR1 (0.52) | MCHR1NOTUMLSSNOS3NOS1 | |
| SCHEMBL24681691 | 0.82 | MCHR1 (0.54) | MCHR1NOTUMLSSNOS3NOS1 | |
| SCHEMBL24681690 | 0.82 | MCHR1 (0.54) | MCHR1NOTUMLSSNOS3NOS1 | |
| SCHEMBL24681150 | 0.81 | MCHR1 (0.59) | RORCMCHR1NOTUMLSSKCNH2 | |
| SCHEMBL24681680 | 0.80 | MCHR1 (0.44) | MCHR1NOTUMLSSNOS3NOS1 | |
| SCHEMBL24681564 | 0.78 | MCHR1 (0.43) | MCHR1NOTUMLSSKCNH2CHIT1 | |
| SCHEMBL24681563 | 0.78 | MCHR1 (0.43) | MCHR1NOTUMLSSKCNH2CHIT1 | |
| SCHEMBL24681105 | 0.75 | MCHR1 (0.47) | MCHR1NOTUMLSSNPY5RKMT2A | |
| SCHEMBL29157657 | 0.73 | LSS (0.55) | MCHR1NOTUMLSSPIK3CDNPY5R | |
| SCHEMBL29157650 | 0.73 | LSS (0.55) | MCHR1NOTUMLSSPIK3CDNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |