Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681150 | 0.84 | MCHR1 (0.59) | MCHR1NOTUMLSSNPY5RKMT2A | |
| SCHEMBL24680793 | 0.81 | NOTUM (0.44) | NOTUMNPY5R | |
| SCHEMBL24681355 | 0.79 | MCHR1 (0.52) | MCHR1NOTUMLSSNPY5RKMT2A | |
| SCHEMBL29157657 | 0.77 | LSS (0.55) | MCHR1NOTUMLSSNPY5RKMT2A | |
| SCHEMBL29157650 | 0.77 | LSS (0.55) | MCHR1NOTUMLSSNPY5RKMT2A | |
| SCHEMBL29157649 | 0.77 | LSS (0.55) | MCHR1NOTUMLSSNPY5RKMT2A | |
| SCHEMBL24681690 | 0.77 | MCHR1 (0.54) | MCHR1NOTUMLSSNPY5RKMT2A | |
| SCHEMBL24681691 | 0.77 | MCHR1 (0.54) | MCHR1NOTUMLSSNPY5RKMT2A | |
| SCHEMBL24680766 | 0.75 | RORC (0.46) | MCHR1NOTUMLSSNPY5RKMT2A | |
| SCHEMBL24681680 | 0.74 | MCHR1 (0.44) | MCHR1NOTUMLSSNPY5RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |