Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.43 |
| ▸ | CHIA | Q9BZP6 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681563 | 1.00 | MCHR1 (0.43) | MCHR1KCNH2CHIT1CHIACYP2D6 | |
| SCHEMBL24681355 | 0.82 | MCHR1 (0.52) | MCHR1CHIT1CHIANOTUMLSS | |
| SCHEMBL24681690 | 0.80 | MCHR1 (0.54) | MCHR1KCNH2CHIT1CHIACYP2D6 | |
| SCHEMBL24681691 | 0.80 | MCHR1 (0.54) | MCHR1KCNH2CHIT1CHIACYP2D6 | |
| SCHEMBL24680766 | 0.78 | RORC (0.46) | MCHR1KCNH2CHIT1CHIANOTUM | |
| SCHEMBL24681150 | 0.78 | MCHR1 (0.59) | MCHR1KCNH2NOTUMLSSMEN1 | |
| SCHEMBL24681680 | 0.77 | MCHR1 (0.44) | MCHR1CHIT1CHIANOTUMLSS | |
| SCHEMBL860755 | 0.76 | CYP2D6 (0.39) | MCHR1KCNH2CYP2D6HRH1SCN9A | |
| SCHEMBL860034 | 0.76 | CYP2D6 (0.39) | MCHR1KCNH2CYP2D6HRH1SCN9A | |
| SCHEMBL24681105 | 0.73 | MCHR1 (0.47) | MCHR1NOTUMLSSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |