Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24680813 | 0.87 | NOTUM (0.47) | NOTUMNPY5RFPR1FPR2DPP4 | |
| SCHEMBL29914613 | 0.87 | NOTUM (0.47) | NOTUMNPY5RFPR1FPR2DPP4 | |
| SCHEMBL24681105 | 0.81 | MCHR1 (0.47) | NOTUMNPY5R | |
| SCHEMBL24680782 | 0.80 | NPY5R (0.48) | NOTUMNPY5RFPR1FPR2 | |
| SCHEMBL29914459 | 0.80 | NPY5R (0.48) | NOTUMNPY5RFPR1FPR2 | |
| SCHEMBL31320003 | 0.79 | NOTUM (0.42) | NOTUMDPP4CHRM2CHRM5CHRM1 | |
| SCHEMBL20236407 | 0.76 | NPY5R (0.50) | NOTUMNPY5RFPR1FPR2DPP4 | |
| SCHEMBL20236406 | 0.76 | NPY5R (0.50) | NOTUMNPY5RFPR1FPR2DPP4 | |
| SCHEMBL31320005 | 0.74 | AR (0.59) | NOTUM | |
| SCHEMBL31320008 | 0.74 | DPP4 (0.45) | NOTUMDPP4CHRM2CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |