Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 8/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914459 | 0.85 | NPY5R (0.48) | NPY5RNOTUMRORCHSD11B1 | |
| SCHEMBL24680782 | 0.85 | NPY5R (0.48) | NPY5RNOTUMRORCHSD11B1 | |
| SCHEMBL26881412 | 0.80 | NPY5R (0.56) | NPY5RPDE10AHTR2BHTR6 | |
| SCHEMBL26881395 | 0.80 | NPY5R (0.56) | NPY5RPDE10AHTR2BHTR6 | |
| SCHEMBL29914530 | 0.79 | PDE10A (0.38) | NPY5RPDE10AHSD11B1 | |
| SCHEMBL24680787 | 0.79 | PDE10A (0.38) | NPY5RPDE10AHSD11B1 | |
| SCHEMBL24681279 | 0.79 | PDE10A (0.38) | NPY5RPDE10AHSD11B1 | |
| SCHEMBL29914526 | 0.79 | PDE10A (0.38) | NPY5RPDE10AHSD11B1 | |
| SCHEMBL29157657 | 0.77 | LSS (0.55) | NPY5RPDE10ANOTUM | |
| SCHEMBL29157649 | 0.77 | LSS (0.55) | NPY5RPDE10ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |