Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 2/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2471510 | 0.94 | SOAT1 (0.34) | SOAT1CCR3TSHRITGB1ITGA4 | |
| SCHEMBL2492124 | 0.88 | SOAT1 (0.32) | SOAT1CCR3TSHRITGB1ITGA4 | |
| SCHEMBL2469967 | 0.86 | SOAT1 (0.35) | SOAT1 | |
| SCHEMBL2497814 | 0.85 | CCR8 (0.34) | SOAT1CCR3ITGB1ITGA4ITGB7 | |
| SCHEMBL2471272 | 0.83 | PNLIP (0.34) | SOAT1TSHR | |
| SCHEMBL2468487 | 0.81 | ALDH1A1 (0.33) | SOAT1CCR3ITGB1ITGA4ITGB7 | |
| SCHEMBL2470579 | 0.81 | KMT2A (0.34) | CCR3ITGB1ITGA4ITGB7 | |
| SCHEMBL2469411 | 0.81 | SMN1; SMN2 (0.34) | SOAT1CCR3ITGB1ITGA4ITGB7 | |
| SCHEMBL2469896 | 0.80 | SLC6A9 (0.43) | ITGB1ITGA4ITGB7 | |
| SCHEMBL2471159 | 0.79 | SLC6A9 (0.36) | ITGB1ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2228065-B1 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB CO (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-1501467-B1 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-2371366-A1 | Heterocyclo inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| EP-2228065-A2 | Heterocyclo inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2010-09-15 | — | — | EP | disclosed |
| US-7005436-B2 | Heterocyclo inhibitors of potassium channel function | BRISTOL MYERS SQUIBB COMPANY (US) | 2006-02-28 | — | — | US | disclosed |