Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30020111 | 1.00 | GRM5 (0.51) | GRM5PIN1SMN1; SMN2LMNAHTT | |
| SCHEMBL18049170 | 0.95 | GRM5 (0.51) | GRM5PIN1SMN1; SMN2LMNAHTT | |
| SCHEMBL8773189 | 0.84 | GRM5 (0.47) | GRM5SMN1; SMN2LMNAMAPK1MEN1 | |
| SCHEMBL17609079 | 0.84 | GRM5 (0.49) | GRM5KDM4EHPGDMAPTL3MBTL1 | |
| SCHEMBL19402607 | 0.78 | MAPK1 (0.47) | SMN1; SMN2HTTTDP1MAPK1MEN1 | |
| SCHEMBL8773165 | 0.77 | GRM5 (0.78) | GRM5MEN1KMT2ANUDT1 | |
| SCHEMBL23504272 | 0.77 | GRM5 (0.65) | GRM5SMN1; SMN2LMNAHTT | |
| SCHEMBL20239278 | 0.77 | PGR (0.47) | GRM5SMN1; SMN2LMNAMAPK1MEN1 | |
| SCHEMBL20239277 | 0.76 | GRM5 (0.45) | GRM5SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL7071630 | 0.76 | MAPK1 (0.48) | GRM5LMNATDP1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022224212-A1 | GPR35 AGONIST COMPOUNDS | HEPTARES THERAPEUTICS LIMITED (GB) | 2022-10-27 | — | — | WO | disclosed |