Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18997958 | 0.87 | MEN1 (0.51) | MAPTNPSR1CYP17A1MEN1KMT2A | |
| SCHEMBL24696014 | 0.80 | ATP4A (0.51) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL1764529 | 0.80 | MAPT (0.59) | MAPTNPSR1CYP17A1MEN1KMT2A | |
| SCHEMBL3130593 | 0.78 | MAPT (0.61) | MAPTNPSR1CYP17A1MEN1KMT2A | |
| SCHEMBL14274836 | 0.76 | CYP1A2 (0.41) | MAPTNPSR1MEN1KMT2AATM | |
| SCHEMBL2609421 | 0.76 | RAB9A (0.53) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL19625306 | 0.75 | MAPT (0.55) | MAPTNPSR1CYP17A1MEN1KMT2A | |
| SCHEMBL23986459 | 0.74 | ATP4A (0.54) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL6644407 | 0.74 | CYP17A1 (0.62) | MAPTNPSR1CYP17A1MEN1KMT2A | |
| SCHEMBL2609412 | 0.73 | NPC1 (0.49) | MAPTMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022256419-A1 | DUAL WNT SIGNALING PATHWAY INHIBITORS AND AMPK ACTIVATORS FOR TREATMENTS OF DISEASE | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2022-12-08 | — | — | WO | disclosed |