Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | THRB | P10828 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | GFER | P55789 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18493542 | 0.84 | HPGD (0.39) | MAP2K2MAP2K1HPGDNPC1CYP2C9 | |
| SCHEMBL2134811 | 0.77 | AAK1 (0.44) | — | |
| SCHEMBL2465151 | 0.76 | GABRA1 (0.36) | HDAC1GAAKDM4EALDH1A1MAPT | |
| SCHEMBL6609844 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MAPTNPC1SMN1; SMN2GLA | |
| SCHEMBL15009906 | 0.74 | SMN1; SMN2 (0.50) | HDAC1GAAKDM4EALDH1A1MAPT | |
| SCHEMBL1266865 | 0.73 | HDAC1 (0.68) | HDAC1ALDH1A1NPC1SMN1; SMN2HDAC3 | |
| SCHEMBL15559293 | 0.73 | AAK1 (0.55) | HDAC1KDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL21857320 | 0.73 | ALDH1A1 (0.49) | GAAKDM4EALDH1A1MAPTTHRB | |
| SCHEMBL3953891 | 0.73 | HDAC1 (0.55) | HDAC1GAAKDM4EALDH1A1HPGD | |
| SCHEMBL978331 | 0.72 | GAA (0.49) | HDAC1GAAKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367599-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | Massachusetts Institute of Technology (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010065117-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-06-10 | — | — | WO | disclosed |