Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | GAA | P10253 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21753178 | 0.82 | GABRA1 (0.37) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL2138866 | 0.81 | GABRA5 (0.43) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL2465632 | 0.78 | ALDH1A1 (0.45) | MAPTGAAALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL2465627 | 0.78 | ALDH1A1 (0.45) | MAPTGAAALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL2469685 | 0.76 | HDAC1 (0.40) | HDAC1MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL10006061 | 0.75 | GABRA5 (0.43) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL8684123 | 0.74 | TDP1 (0.43) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL1805369 | 0.74 | KMT2A (0.49) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL14881372 | 0.73 | TDP1 (0.38) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL25229723 | 0.73 | RAB9A (0.40) | GABRA1GABRA5GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367599-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | Massachusetts Institute of Technology (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010065117-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-06-10 | — | — | WO | disclosed |