Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172790 | 0.89 | CHRNB2 (0.53) | TP53MDM2 | |
| SCHEMBL22201130 | 0.89 | CHRNB2 (0.53) | TP53MDM2 | |
| SCHEMBL11488897 | 0.87 | KDM4E (0.56) | — | |
| SCHEMBL24365232 | 0.87 | KDM4E (0.56) | — | |
| SCHEMBL537320 | 0.83 | SIGMAR1 (0.49) | GBA1TP53MDM2SIGMAR1ACHE | |
| SCHEMBL6269988 | 0.83 | SIGMAR1 (0.53) | GBA1TP53MDM2SIGMAR1NR1H2 | |
| SCHEMBL23064631 | 0.80 | MEN1 (0.55) | SIGMAR1 | |
| SCHEMBL23064641 | 0.80 | DRD2 (0.54) | SIGMAR1 | |
| SCHEMBL16226782 | 0.79 | SIGMAR1 (0.55) | TP53MDM2SIGMAR1NR1H2NR1H3 | |
| SCHEMBL9070276 | 0.79 | DRD2 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412663-B1 | NITROGEN-CONTAINING HETEROCYCLE AND CARBOCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2022-09-07 | — | — | EP | disclosed |