Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30015307 | 1.00 | HRH3 (0.48) | HRH3PIK3CAKDM4EHTTHSD17B10 | |
| SCHEMBL24698056 | 0.87 | PIK3CA (0.35) | HRH3PIK3CAKDM4EMEN1KMT2A | |
| SCHEMBL24698168 | 0.87 | HRH2 (0.43) | HRH3KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL24698853 | 0.85 | ALDH1A1 (0.37) | HRH3PIK3CAKDM4EHSD17B10TSHR | |
| SCHEMBL24697693 | 0.85 | MEN1 (0.34) | HRH3PIK3CAKDM4EMEN1KMT2A | |
| SCHEMBL30016322 | 0.82 | BRD4 (0.36) | HRH3PIK3CAMEN1KMT2AMTOR | |
| SCHEMBL24697563 | 0.82 | BRD4 (0.36) | HRH3PIK3CAMEN1KMT2AMTOR | |
| SCHEMBL24699331 | 0.82 | MEN1 (0.39) | HRH3KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL30015772 | 0.82 | MEN1 (0.39) | HRH3KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL24698400 | 0.82 | PIK3CA (0.49) | HRH3PIK3CAKDM4EHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |