Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | LATS1 | O95835 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698853 | 0.86 | ALDH1A1 (0.37) | MEN1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL24698018 | 0.85 | HRH3 (0.48) | MEN1KMT2AHRH3PIK3CAALDH1A1 | |
| SCHEMBL30015307 | 0.85 | HRH3 (0.48) | MEN1KMT2AHRH3PIK3CAALDH1A1 | |
| SCHEMBL24698056 | 0.83 | PIK3CA (0.35) | MEN1KMT2AHRH3PIK3R1PIK3CA | |
| SCHEMBL24698168 | 0.83 | HRH2 (0.43) | MEN1KMT2AHRH3HRH2ALDH1A1 | |
| SCHEMBL24698397 | 0.82 | MEN1 (0.34) | MEN1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL24699439 | 0.81 | PIK3CA (0.41) | HRH3PIK3R1PIK3CAMAP3K12HRH2 | |
| SCHEMBL24698802 | 0.81 | MTOR (0.40) | HRH3MAP3K12TRPV1PDK1PDK2 | |
| SCHEMBL29134842 | 0.81 | PIK3CA (0.41) | HRH3PIK3R1PIK3CAMAP3K12HRH2 | |
| SCHEMBL30016131 | 0.81 | MTOR (0.40) | HRH3MAP3K12TRPV1PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |