Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24699408 | 0.91 | HTR2A (0.34) | ALDH1A1MEN1KMT2APIK3R1PIK3CA | |
| SCHEMBL24699352 | 0.79 | BMPR1A (0.35) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL24698853 | 0.78 | ALDH1A1 (0.37) | KDM4EHSD17B10TRPV1ALDH1A1MEN1 | |
| SCHEMBL24698745 | 0.78 | MEN1 (0.30) | TRPV1MEN1KMT2A | |
| SCHEMBL24698822 | 0.78 | ATR (0.39) | KDM4EALDH1A1MEN1KMT2APDCD1 | |
| SCHEMBL30017019 | 0.78 | MTOR (0.38) | KDM4ETRPV1 | |
| SCHEMBL24698700 | 0.78 | MTOR (0.38) | KDM4ETRPV1 | |
| SCHEMBL24699361 | 0.78 | HRH3 (0.36) | KDM4ETRPV1ALDH1A1MEN1KMT2A | |
| SCHEMBL24699075 | 0.77 | KCNH2 (0.36) | HSD17B10TRPV1ADORA2AADORA1ALDH1A1 | |
| SCHEMBL24699489 | 0.77 | GSK3B (0.35) | TRPV1ALDH1A1CREBBPLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |